Nanoparticles Create Effective CAR T Cells in Living Mice
Researchers have developed a method to genetically engineer cancer-fighting immune cells in living animals using nanoparticles that carry DNA. The new study shows that the resulting immune cells, known as CAR T cells, eliminated leukemia in mice.
Celyad Reports Impressive Preliminary CAR-T Results in Solid Tumors
Celyad has announced no toxicity and stable disease in colorectal cancer patients after just 3 months of its first trial testing CAR-T in solid tumors.
Successful First in Man Trial for MSC-based Cartilage Repair
Previous studies from the laboratory of Daniel B. F. Saris (University Medical Center Utrecht, The Netherlands) reported that a novel stem cell combination represented a safe and efficient means to repair cartilage in preclinical and early clinical studies
Engineers Create Artificial Skin That "Feels" Temperature Changes
A team of engineers and scientists at Caltech and ETH Zurich have developed an artificial skin capable of detecting temperature changes using a mechanism similar to the one used by the organ that allows pit vipers to sense their prey.
First-ever trial of drug using iPS cells to begin at Kyoto University
Kyoto University researchers are set to begin the world’s first clinical trial of a drug identified using iPS cells to treat a rare bone disease, the university said Tuesday.
FDA panel unanimously endorses Novartis T-cell cancer therapy pioneered at Penn, CHOP
For the estimated 600 children who battle terminal leukemia each year in the United States, there is new hope.
In a resounding vote of confidence for a first-of-its-kind cancer treatment, a U.S. Food and Drug Administration advisory committee on Wednesday unanimously recommended approval of Novartis Pharmaceutical’s T-cell therapy for acute lymphocytic leukemia (ALL).
A protein that stem cells require could be a target in killing breast cancer cells
For years, cancer experts have realized that cancerous cells behave in certain ways like stem cells, unspecialized cells that when exposed to certain signals, can "differentiate."
Lab-grown blood stem cells produced at last
After 20 years of trying, scientists have transformed mature cells into primordial blood cells that regenerate themselves and the components of blood. The work, described today in Nature, offers hope to people with leukaemia and other blood disorders who need bone-marrow transplants but can’t find a compatible donor. If the findings translate into the clinic, these patients could receive lab-grown versions of their own healthy cells.
Organoid model systems are taking research to the next dimension
Using the novel technology of three-dimensional (3D) “mini-organs”, termed organoids, scientists are getting closer to understanding the detailed mechanistic pathways of how stem cells form and maintain complex tissues like organs.
Study shows benefit in children with CNS-relapsed ALL
Another Win for CAR-T Therapy
The investigational chimeric antigen receptor T cell (CAR-T) therapy CTL019 induced "potent and durable responses" in children with central nervous system (CNS) involvement in relapsing/refractory acute lymphoblastic leukemia (ALL)
