Regenerative Medicine and Stem Cells Technologies

Researchers at Oregon State University have made an important advance toward understanding why certain cells in the nervous system are prone to breaking down and dying, which is what happens in patients with ALS and other neurodegenerative disorders.

A new study released this week in STEM CELLS Translational Medicine (SCTM) offers hope for anyone who has suffered a serious corneal injury that did not respond well to conventional treatment.

Scientists have successfully constructed a three-dimensional human epidermis based on predictions made by their mathematical model of epidermal homeostasis, providing a new tool for basic research and drug development.

Scientists at the Yale School of Medicine and Veterans Affairs Connecticut Healthcare System have successfully demonstrated that it is possible to pinpoint genes that contribute to inter-individual differences in pain.

Currently approved treatments for acute ischemic stroke, a leading cause of death associated with persistent disability [1], suffer from a narrow treatment time‐window and benefit to only a small patient subset [2].

A novel investigation into the impacts of neuronal mutations on autism-related characteristics in humans has been described in the open-access journal eLife.

Researchers have unlocked mysteries surrounding how a pregnant mothers cells and her fetus cells communicate throughout pregnancy. With this new information, The University of Texas Medical Branch at Galveston team and their colleagues in South Korea can develop new non-invasive methods of monitoring and improving the health of the fetus using this mode of communication.

We previously reported that Herpes simplex virus type‐1 (HSV‐1) infection of cultured neurons triggered intracellular accumulation of amyloid‐β protein (Aβ) markedly impinging on neuronal functions. Here, we demonstrated that HSV‐1 affects in vitro and in vivo adult hippocampal neurogenesis by reducing neural stem/progenitor cell (NSC) proliferation and their neuronal differentiation via intracellular Aβ accumulation.

In early mammalian development, timing is everything. For healthy development to occur—whether it be three weeks for a mouse or nine months for a human—embryos follow the lead of oscillating genes, which turn on and off in precise cycles and trigger different development milestones. Oscillating genes are conductors keeping time in a symphony of growth.

The generation of three-dimensional cerebral organoids from human pluripotent stem cells has enabled the modeling of both cerebral development and the pathogenesis of related diseases; however, limitations in this field include the inability to functionally evaluate neural network activity.