Regenerative Medicine and Stem Cells Technologies

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Mayo researchers now report that using the measles virus vector; theyve trimmed that multi-vector process with four reprogramming factors down to a single "one cycle" vector process.

Two types of cells are active in the brain: nerve cells and glial cells. Glial cells have long been regarded primarily as supportive cells, but researchers increasingly recognize that they play an active role in the communication between neurons in the brain.

Autologous stem cell transplantation (ASCT) may be beneficial for some patients with nodal peripheral T-cell lymphoma (PTCL) in the first complete remission (CR1), according to a study published online Jan. 29 in Cancer.

An Osaka University-led research team has developed a system for simply and efficiently producing human norovirus. By coaxing human induced pluripotent stem cells (iPSCs) to develop into a type of cell that usually lines the intestine, they created a cellular environment that can be used for producing the virus, studying how it interacts with human cells, and investigating potential vaccines.

Why are fat deposits more likely to occur after tears of the shoulders rotator cuff, compared to other types of muscle injuries? An increased propensity of stem cells within with rotator cuff muscles to develop into fat cells may explain the difference, reports a study in the February 6, 2019 issue of The Journal of Bone & Joint Surgery.

Embryonic stem cells (ESCs) are the very definition of being full of potential, given that they can become any type of cell in the body. Once they start down any particular path toward a type of tissue, they lose their unlimited potential. Scientists have been trying to understand why and how this happens in order to create regenerative therapies that can, for example, coax a persons own cells to replace damaged or diseased organs.

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.

Functional B-1 cells derived from mouse embryonic stem cells are capable of long-term engraftment and secrete natural antibodies after transplantation in mice, researchers report February 7th in the journal Stem Cell Reports. Scientists are interested in B-1 cells generated from pluripotent stem cells because they could be tested as a therapeutic for a broad range of immunological disorders.

There is good news for all patients suffering from relapsed/refractory non-Hodgkin lymphoma. A new drug is one step closer to helping them, after it has received FDA approval.