Newly identified stem cells may hold clues to colon cancer
Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer.
Amish nemaline myopathy natural history study finds promise for gene therapy treatment
A new comprehensive natural history study about Amish nemaline myopathy (ANM) in the Old Order Amish population focuses on the promise of gene therapy for this lethal disorder.
creation spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs)
The achievement, described in the August 6 online issue of Nature Methods, advances not only basic research like biomedical applications of in vitro disease modeling, but may constitute an improved, clinically translatable cell source for replacement strategies in spinal cord injuries and disorders.
Role of Astrocytes in Alexander Disease Revealed
City of Hope researchers have developed a stem cell model to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS).
Scientists uncover the role of a protein in production and survival of myelin-forming cells
The nervous system is a complex organ that relies on a variety of biological players to ensure daily function of the human body. Myelin—a membrane produced by specialized glial cells—plays a critical role in protecting the fibers that help carry messages throughout the body.
Comprehensive pediatric CAR T guidelines developed
Almost one year after the U.S. Food and Drug Administration (FDA) approval of chimeric antigen receptor (CAR) T-cell therapy for children with acute lymphoblastic leukemia (ALL), researchers at The University of Texas MD Anderson Cancer Center and the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI) today published treatment guidelines for managing the treatment in the online issue of Nature Reviews Clinical Oncology.
Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice
In a paper published in the journal ACS Central Science, the researchers described the probes effectiveness in identifying cancer stem cells in cultures of multiple human cancer cell lines as well as in live mice.
Three- dimensional printed implants shown to help grow real bone
Chemically coated, ceramic implants successfully guided the regrowth of missing bone in lab animals while "steadily dissolving," researchers report.
Regulation of the Hoxb gene cluster maintains blood-forming cells and inhibits leukemia
Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.
Growing kidney tissue simpler and faster will help fight disease
New treatments for kidney diseases and inherited kidney disorders could result from new research that is revolutionising the way human kidney tissue is grown from stem cells.
