Regenerative Medicine and Stem Cells Technologies

Cardiac tissues generated from human induced pluripotent stem cells (iPSCs) can serve as platforms for patient-specific studies of physiology and disease1-6. However, the predictive power of these models is presently limited by the immature state of the cells1, 2, 5, 6.

Neural stem cells are characterized as self-renewing cell populations with the ability to differentiate into the multiple tissue types of the central nervous system. These cells can differentiate into mature neurons, astrocytes, and oligodendrocytes.

Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the bodys normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries

Gastric diseases, including peptic ulcer disease and gastric cancer, are highly prevalent in human beings. Despite this, the cellular biology of the stomach remains poorly understood relative to other gastrointestinal organs such as the liver, intestine, and colon.

Our researchers have revealed the identities of new subsets of immune cells at the frontline of our bodys defenses against infection.

Cells switch fates and acquire new identities during organogenesis and regenerationas a critical trait, although the mechanisms underlying such conversions are poorly understood.

Self-renewal and multi-potential differentiation are two important features of hematopoietic stem/progenitor cells (HS/PCs) which make them as an ideal source of stem cells for treatment of many hematologic disorders and cancers

The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively.

The study, which was recently published in the journal Nature Communications, outlines a layer-by-layer printing method that features fine-grain, programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.

We previously revealed that stromal cell-derived factor-1(SDF-1) is involved in the changes in the number of bone marrow stem cells during the bone repair process in mice.