Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Regulation of hematopoiesis during human development remains poorly defined. Here in this study scientise applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.
Self-organizing human heart organoids in a dish
Biologists have used human pluripotent stem cells to grow sesame-seed-sized heart models, called cardioids, that spontaneously self-organize to develop a hollow chamber without the need of experimental scaffolds.
Urothelial cancer organoids show promise as a tool for bladder cancer research
Researchers from the University Medical Center Utrecht (Netherlands) have provided proof of concept of tissue-based bladder tumoroids mimicking parental tumors.
Unusual stem cell adhesions may shed light on pluripotency
Peculiar junctions between pluripotent stem cells may help researchers understand pluripotency and differentiation.
