Regenerative Medicine and Stem Cells Technologies

Researchers from Tokyo Metropolitan University (Japan) have quantitatively characterized the heterogeneity in the responsiveness of mesenchymal stem cells (MSCs) to the elastic modulus of culture substrates. The localization dynamics of YAP and RUNX2 proteins in cell nuclei and how this changed with stiffness, provides a basis to design the substrate elastic modulus to control the state of stem cells.

Having studied the effectiveness of CAR-T therapies in children with leukemia, researchers and clinicians at University College London (UCL) and Great Ormond Street Hospital (both London, UK) have discovered a subset of T cells that are likely to contribute to the success of the treatment.

In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, Ph.D., demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly.

A new study published in Scientific Reportsclaims to have isolated and characterized stem cells from human urine. The discovery, made by researchers from Heinrich Heine Universität Dusseldorf (Germany), would allow for the non-invasive collection of patient-specific stem cells that could be easily transformed into iPSCs or differentiated for regenerative therapies.

A team of researchers from the Center for Stem Cell and Regenerative Medicine (CSCRM) at Tokyo Medical and Dental University (Japan) has recently confirmed the safety of their novel stem cell therapy to treat knee pain caused by osteoarthritis.

Researchers in China and the USA have successfully grown chimeric embryos for up to 20 days by integrating human stem cells into primate embryos.

Researchers from the University of California Los Angeles (UCLA; CA, USA) and Great Ormond Street Hospital (GOSH; London, UK) have collaborated to develop a new gene therapy for the treatment of severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID).

Scientists at the Klara Medical Center (KMC; Czestochowa, Poland) have shown that mesenchymal stem cells (MSCs) can be used for the treatment of muscular dystrophies – a group of progressive muscle diseases caused by a genetic mutation, resulting in muscle weakness.

Despite the improvements made in modern surgical techniques, diagnostics and medications for myocardial infarction, many individuals still struggle with the long-term effects of tissue damage. Now, researchers have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.