Regenerative Medicine and Stem Cells Technologies

Using stem cells that can turn into other cells in the brain, researchers developed two experimental models a living 3D "organoid" model of the brain and a mouse brain model with implanted human cells to investigate early brain development linked to Down syndrome, according to the study in the journal Cell Stem Cell. The study focused on human chromosome 21 gene OLIG2.

Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order. Accordingly, such cancer stem cells are responsible for tumor progression and produce specific types of more differentiated cancer cells whose fates are predetermined.

The genes necessary for the growth and survival of stem cells are influenced by the biomaterials on which theyre cultured, researchers at the University of Toronto have found.

For people with severe epilepsy, no medication is effective – but a radical approach of implanting stem cells into the brain could stop seizures at their source.

“Stem cells, tissue engineering and regenerative medicine in cardiovascular system” is the title of a symposium held to provide the foundation for learning about and developing the updated activities of this field.

Secretary of the council for stem cells science and technology accelerated the pace of the development and flourishing of innovation and technology ecosystem in the province in the field of stem cells during his trip to North Khorasan.

The ability to modify multiple genetic elements simultaneously would help to elucidate and control the gene interactions and networks underlying complex cellular functions. However, current genome engineering technologies are limited in both the number and the type of perturbations that can be performed simultaneously.

Researchers from the laboratory of Karl Tryggvason (Karolinska Institute, Stockholm, Sweden) have previously reported on the generation and characterization of basement membrane laminin isoforms that can promote stem cell differentiation in vitro [1-3].

Tendon healing follows a complex series of coordinated events, which ultimately produces a mechanically inferior tissue more scar‐like than native tendon. More regenerative healing occurs when anti‐inflammatory M2 macrophages play a more dominant role.

Using CRISPR gene editing, a team from Penn Medicine and Childrens Hospital of Philadelphia (CHOP) have thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. This proof-of-concept study, published in Science Translational Medicine this week, showed that in utero editing could be a promising new approach for treating lung diseases before birth.