Vortex-Focusing Microfluidics Yields Precisely Sized Liposomes at Scale
When synthesizing nanoscale liposomes, the ability to control vesicle size helps define their pharmaceutical properties. Conventional microfluidic liposome synthesis methods, however, are limited in terms of the sizes they can produce and the consistency of those sizes.
A new microfluidic vortex-focusing technique resolves those challenges, generating liposomes at precise sizes with negligible size variance. The method, which extends a related microfluidic technique outlined in the recently released book, Liposomes, can be used up to the laminar flow limit, for manufacturing-scale production.
Its developers, led by Don DeVoe, PhD, professor, associate chair of research & administration, University of Maryland, generated liposomes as small as 27 nm for lipids incorporating polyethylene glycol (PEG), and between 61 nm and 127 nm for those without PEG. Production rates exceeded 20g/hour, according to a paper in Nature Communications. Consequently, these small nano-sized liposomes can penetrate the skin as well as cross the blood-brain barrier. Their smaller size range can also enhance cell uptake for reduced toxicity when compared to larger nanoparticles.
https://www.genengnews.com/
ارسال به دوستان