Urothelial cancer organoids show promise as a tool for bladder cancer research
Researchers from the University Medical Center Utrecht (Netherlands) have provided proof of concept of tissue-based bladder tumoroids mimicking parental tumors.
Researchers from the University Medical Center Utrecht (Netherlands) have provided proof of concept of tissue-based bladder tumoroids mimicking parental tumors. As preclinical model systems for bladder cancer are crucial for developing therapeutic strategies tailored to individual tumor characteristics, these findings provide a promising new avenue for bladder cancer pathogenesis research.
Their research was published in the journal National Library of Medicine.
Bladder cancer ranks among the top ten most common tumor types worldwide and continues to represent a growing healthcare problem.
Bladder tumors are genetically and molecularly very heterogenous, causing precision medicine to fail in the area of bladder cancer. Currently, therapeutic decision-making involves assessing a single fragment of tumor tissue.
In their research, the team collaborated with the Hubrecht Institute to provide proof of concept of tissue-based bladder tumoroids mimicking parental tumors.
Urothelial tumoroids, a special type of cancer organoid, were used for the research.
To accurately reflect aspects of bladder cancer pathogenesis, the researchers have developed a living biobank containing bladder organoids and tumoroids grown from over 50 patient samples out of a cohort of eligible bladder cancer patients. 3D organoid tissue cultures were used to stimulate small-size organs in a dish.
Organoid technology has the potential to fill the gap between cancer genetics and patient trials, bolster cell-line and xenograft-based drug studies and enable personalized therapy design.
The research provided favorable results as the histological and immunofluorescence analysis indicated that the heterogeneity and subclassification of tumoroids mimicked those of corresponding parental tumor samples.
This research paves the way for bladder cancer pathogenesis and drug-resistance research, as well as for future precision medicine approaches.
Ref: https://www.regmednet.com/urothelial-cancer-organoids-show-promise-as-a-tool-for-bladder-cancer-research/
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