UT Southwestern stem cell biologists develop embryo model
Peri-gastruloids advance understanding of early human development, tissue formation, and differentiation for regenerative medicine
University of Texas Southwestern Medical Center biologists have developed a new stem cell-based embryo model for studying early human development, tissue formation and differentiation, offering valuable contributions to the field of developmental biology and regenerative medicine.
Peri-gastruloids are primitive embryonic structures with the potential to form many of the different cell types of the body, thereby providing a window into the earliest steps of embryogenesis. The findings on peri-gastruloids, published in the journal Cell, could impact a wide range of diseases and conditions that involve early human development, including developmental disorders, birth defects, genetic disorders and diseases that arise during embryonic development such as certain types of cancer or neurological disorders, researchers noted. Disease modeling and drug testing also can benefit from peri-gastruloid research.
Researchers also can expose peri-gastruloids to various drugs or compounds to evaluate their efficacy and potential side effects. This can help in identifying promising drug candidates and ensuring the safety of pharmaceutical interventions before they are tested in human clinical trials.
https://www.asbmb.org/asbmb-today/science/081923/ut-southwestern-stem-cell-biologists-develop-embry
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