Stem cells could help prevent diabetes onset from cancer immunotherapy
Japanese researchers have shown that stem cell therapy could prevent type 1 diabetes in mice. Type 1 diabetes can be a severe side effect of some types of cancer treatment.
Japanese researchers have shown that stem cell therapy could prevent type 1 diabetes in mice. Type 1 diabetes can be a severe side effect of some types of cancer treatment. This occurs due to a build-up of immune cells in the pancreas, which disrupts insulin production. There was also significantly reduced build-up of T cells and macrophages in pancreatic islets of MSC-treated mice. In the new study, researchers at Osaka University investigated whether mesenchymal stem cells (MSCs) could help prevent this profound side effect. These specialized stem cells play roles in tissue regeneration and modulation of immune functions.
The team started by inducing diabetes in mice by giving them a purified PD-L1 monoclonal antibody, a commonly used immune checkpoint inhibitor. Some mice were then treated with MSCs derived from human fat tissue, and the researchers examined the immune cells in their pancreatic secretions. Of the mice that received just the antibody, 64 percent (or 16 out of 25 animals) developed type 1 diabetes, compared to just 19 percent of mice (or four out of 21) that also received MSCs.
There was also significantly reduced build-up of T cells and macrophages in the pancreatic islets of MSC-treated mice. Of course, the treatment is still a long way from ever being used in humans – this was just an early animal test and a reasonably small one. Much more work will need to be conducted to investigate the potential for MSCs to help prevent this rare but severe side effect.
https://newatlas.com/medical/stem-cells-prevent-diabetes-cancer-immunotherapy/
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