Sorting Cancers by Microenvironment Potentially Shifts the View on Immunotherapy
Researchers at the University of California, San Francisco (UCSF) demonstrated a new approach to cancer immunotherapy. The researchers surveyed 364 tumor biopsies from patients and categorized them into their immune microenvironment.
Their findings are published in the journal Cell in a paper titled, "Discovering dominant tumor immune archetypes in a pan-cancer census." The researchers sought to determine why immunotherapies work for some people and not others. The researchers observed a variety of cancers come in prescribed forms. They characterized different microenvironments in the tumors, scrutinizing which immune cells were present and expressed genes. The researchers sorted the tumors into 12 groups and called them archetypes. They observed that the tumors contained a wide range of immune cells, such as macrophages and NK and B cells— exceeding the T cells, which are the priority of current immunotherapies.
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