New Stem Cell Mechanism in Your Gut
Stem cells are a hot topic for creating medical treatments. However, scientists still do not fully understand how they choose to divide or differentiate to renew organs.
Stem cells are a hot topic for creating medical treatments. However, scientists still do not fully understand how they choose to divide or differentiate to renew organs. Researchers have now found a new biophysical mechanism that regulates stem cells in the intestines of mice. This could have implications for possible new treatments. The intestinal epithelium is just one layer of cells thick and constantly renewed.
It is all over the villi which look like tiny tentacles covering the insides of the small and large intestines. Some stem cells remain as stem cells in the crypt and the others are pushed outwards towards to tip of the surrounding villi. Cells in the epithelium layer of the intestinal crypt actively move around in random directions, just like on a conveyor belt. In the small intestine, the molecular signal regulating the movements is stronger than in the large intestine, so cells can move more frequently back into the crypt. Using their model, scientists could predict the number of actually working stem cells in the small and large intestines.
https://ist.ac.at/en/news/new-stem-cell-mechanism-in-your-gut/
ارسال به دوستان