New Immunotherapy Treatment Brings Hope to Patients With Advanced Non-Small Cell Lung Cancer
Although immunotherapies have shown promise in treating non-small cell lung cancer (NSCLC), many patients still do not respond well, and those who do may eventually develop resistance. In a new study, Yale Cancer Center researchers at Yale School of Medicine tested a new immunotherapy, NC318, in combination with the targeted immunotherapy, pembrolizumab (KEYTRUDA). The study's findings suggest that NC318, both alone and in combination with pembrolizumab, improved response rates and clinical outcomes for some patients with NSCLC.
The researchers present their findings at the IASLC 2023 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer in Singapore on Sept. 12. The research team partnered with the developer of NC318, NextCure, on this phase II trial.
In the trial, researchers administered NC318 either alone or in combination with pembrolizumab to patients with advanced NSCLC that had progressed after receiving checkpoint inhibitor therapy. Among the 11 patients who received NC318 alone, one patient had a partial response, two had stable disease (tumor size did not grow or shrink), and eight patients had progressive disease (at least a 20% growth in tumor size).
Among the 18 patients who received the NC318-pembrolizumab combination treatment, three patients had a partial response (one after initial pseudo-progression), six patients had stable disease, and nine patients had progressive disease. Two of the patients with stable disease had ongoing stability at 21.6 months and 7.6 months, respectively.
Some patients experienced treatment-related adverse events, but researchers say the overall tolerability was good, similar to standard immunotherapy.
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