Human urine-derived stem cells have robust regenerative potential
The Wake Forest Institute for Regenerative Medicine (WFIRM) researchers were the first to identify that stem cells in human urine have the potential for regenerative tissue effects. Their findings provide a novel perspective to evaluate the capacity of telomerase-positive human urine-derived stem cells. Telomerase is an enzyme essential for the self-renewal and potential of different types of stem cells and is closely related to longevity.Telomerase activity is also closely related to longevity. The research team investigated the regenerative significance of telomerase activity, particularly in terms of characteristic cell surface marker expression, multipotent differentiation capability, chromosomal stability, and safety of in vivo formation of tumors.
WFIRM's Yuanyuan Zhang, Ph.D., lead author of the paper published by Frontiers in Cell and Developmental Biology, said that human urine-derived stem cells could be easily isolated from urine samples which offer clear advantages over stem cells from other sources, like bone marrow or fat tissue which often require a surgical procedure for collection. "Being able to use a patient's stem cells for therapy is considered advantageous because they do not induce immune responses or rejection," said WFIRM Director Anthony Atala, MD, co-author of the paper. "Additionally, the non-invasive collection method is suitable for rapid clinical translation."
The study demonstrates that human primary urinary stem cells with positive telomerase activity act as a distinct subpopulation with potential regeneration capacity in cell growth and its ability to become other cells, Zhang said. It will be beneficial to better understand alterations in this cell subpopulation throughout the human lifespan and how they translate into aging, kidney damage, or cancer.
https://phys.org/news/2022-06-human-urine-derived-stem-cells-robust.html
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