Generating 3D pituitary organoids from stem cells
Human pluripotent stem cells have been successfully converted into purified hormone-secreting pituitary tissue.
The pituitary gland plays an important role in hormone regulation and controlling different processes in the body, including metabolism, reproduction and growth. Decreased function of the pituitary gland leads to a condition known as hypopituitarism, which results in a deficiency of the hormones secreted by the gland.
The team induced pituitary-hypothalamic tissue from human pluripotent stem cells (hPSCs), which were then purified with cell sorting utilizing a pituitary cell-surface marker to acquire a pituitary cell population. These purified pituitary cells aggregated to form 3D pituitaries that had the ability to secrete ACTH.
The study was funded by several organizations including Japan Agency for Medical Research and Development, the Japan Science and Technology Agency and Nagoya University Hospital. The findings from the study mark a significant step forward in translational research, with the study suggesting that human pituitary tissue that is responsive to the surrounding environment could be generated from hPSCs and purified for clinical use for hypopituitarism.
https://www.regmednet.com/generating-3d-pituitary-organoids-from-stem-cells/
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