Engineering Researchers Develop Porous Nanoparticles For Regenerative Medicine
Stem cells can develop into many different types of cells in the body. For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. New nanotechnology developed by a team of researchers from Texas A&M University could leverage the body’s regenerative potential by directing stem cells to form bone tissue.
The researchers have developed water-stable, 2D covalent organic framework (COF) nanoparticles that can direct the differentiation of human mesenchymal stem cells into bone cells. They were able to load an osteo-inducing drug called dexamethasone into the porous structure of the COF to further enhance bone formation.
These nanoparticles could prolong delivery of drugs to human mesenchymal stem cells, which are commonly used in bone regeneration. The sustained delivery of the drug resulted in enhanced stem cell differentiation toward bone lineage, and this technique can be used for bone regeneration.
These findings are important for the future design of biomaterials that can give directions for tissue regeneration and drug delivery applications.
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