Depleting decidual precursor cells linked with pregnancy loss
Scientists from Warwick Medical School at the University of Warwick (Coventry, UK) have discovered that the reduction of decidual precursor cells in the womb lining may lead to recurring pregnancy loss. This research was recently published in the journal STEM CELLS.
Scientists from Warwick Medical School at the University of Warwick (Coventry, UK) have discovered that the reduction of decidual precursor cells in the womb lining may lead to recurring pregnancy loss. This research was recently published in the journal STEM CELLS.
“This raises the possibility that they can be harnessed to prevent pregnancy disorders,” commented corresponding author of the study, Jan J Brosens (Warwick Medical School).
During a typical pregnancy, the lining of the womb – known as the endometrium – remodels itself thoroughly. During this process, endometrial stromal cells differentiate into specialized decidual cells that provide plasticity to the womb – helping the tissue to support the embryos rapid growth.
“While the magnitude of tissue remodeling required for pregnancy makes it likely that poised progenitor and highly proliferative decidual precursor cells are critical for the formation of a robust maternal–fetal interface, the underlying mechanisms behind this are unclear,” explained Brosens.
To tackle this, Brosnens team identified and characterized a distinct population of highly proliferative mesenchymal cells (hPMCs) present during the window of embryo implantation.
“Our findings indicate that hPMCs are derived from circulating bone marrow-derived stem cells and recruited into the lining of the womb at the time of embryo implantation. These cells appear critical in pregnancy to accommodate the rapidly growing placenta,” Brosens explained. “We also found that these rare but highly specialist cells are depleted in the womb lining of women with recurrent pregnancy.”
These results indicate that hPMCs play a direct role in the formation of a strong maternal–fetal interface.
“These are very exciting findings,” concluded co-author Siobhan Quenby (University of Warwick). “We have already demonstrated that we can increase these highly proliferative cells in the lining of womb before pregnancy. These new findings explain why these highly proliferative cells are so important for the prevention of miscarriage and possibly spontaneous preterm labor, two devasting pregnancy disorders that affect many women and couples all over the world.”
https://www.regmednet.com/depleting-decidual-precursor-cells-linked-with-pregnancy-loss/
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