Altering metabolism in immune cells helps damaged nerves recover
Peripheral nerves—the nerves outside the brain and spinal cord—have the capacity for regeneration, but the rate of renewal is so slow that many nerve injuries lead to incomplete recovery and permanent disability for patients. Johns Hopkins Medicine researchers have determined that macrophages—white blood cells that surround and kill microorganisms, remove dead tissues and stimulate the action of other immune system soldiers—can be modified to support and accelerate the regeneration of peripheral nerves in mice following injury.
In a study published Sept. 7, 2021, in the Journal of Clinical Investigation, Brett Morrison M.D., Ph.D., associate professor of neurology at the Johns Hopkins University School of Medicine; Mithilesh Kumar Jha, Ph.D., postdoctoral research fellow at Johns Hopkins; and colleagues investigated whether altering the metabolism of macrophages in mice would impact the recovery from nerve injury.
Ref:https://medicalxpress.com/news/2021-10-metabolism-immune-cells-nerves-recover.html
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