Gene Map Predicts Heart Problems or Stroke in Type 2 Diabetics
A risk score based on a gene map predicted the likelihood of high blood pressure leading to heart problems or stroke in people with Type 2 diabetes, according to a study published today in Hypertension
“Increased genetic risk of high blood pressure may predispose some people with Type 2 diabetes to a higher risk of heart attack, stroke or cardiovascular death,” said Arora. “We conducted the study to determine if this genetic risk score can identify people with Type 2 diabetes who have a higher risk for cardiovascular events and if tight control of blood sugar impacts the link between genetic hypertension risk and cardiovascular outcomes.”
A genetic variant map of more than 1,000 common genetic variants known to affect blood pressure was compared to the DNA of the study participants to determine genetic risk. More matches between the participant’s DNA and the map of known blood pressure genetic variants generated a higher genetic risk score.
The genetic risk score identified study participants with a higher risk of cardiovascular events: For people with higher-than-average genetic risk scores, each degree higher was associated with a 12% higher risk of heart disease or stroke events.
The researchers said further evaluation of genetic risk scores in people who do not have Type 2 diabetes is needed to be able to apply these findings more broadly.
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