The advantages of gamma-delta T-cell therapy
Numerous experimental studies have demonstrated the anticancer potential of gamma-delta T lymphocytes. Indeed, gamma‑delta T cells can recognise several specific tumour‑associated molecules including non-peptidic antigens (such as isopentenyl pyrophosphate – IPP) and immune surveillance stress signals (such as HSP60/70, MICA, MICB and ULBP) present on the surface of transformed cells. The gamma-delta T cell overexpresses IL-2 receptors and this cytokine is necessary to activate them.
On recognising a tumour cell, gamma‑delta T cells exert their anticancer properties via release of both perforin and granzyme, a serine protease which enters the target cell to trigger cell death (apoptosis).
Our research efforts are focused entirely on targeting tumours in ways that may result in an improved therapeutic index and that have potential applications in solid tumours as well as haematological malignancies.
https://www.drugtargetreview.com/article/106657/the-advantages-of-gamma-delta-t-cell-therapy/
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