Roadmap to HIV eradication via stem cell therapy
(Study uncovers stem cell`s ability to restore immunity and repair gut damage caused by HIV)
In a groundbreaking study, a team of UC Davis researchers has discovered a special type of stem cell that can reduce the amount of the virus causing AIDS,boosting the body's antiviral immunity and repairing and restoring the gut's lymphoid follicles damaged. The study, published June 22 in JCI Insight, showed the mechanism through which mesenchymal stem/stromal cells (MSCs) enhance the body's immune response to the virus.
The lymphoid tissue in the gut is an early site for viral replication and the establishment of viral reservoirs. Dandekar's group has previously shown that an HIV infection causes severe loss of gut mucosal T immune cells and disrupts the gut epithelial barrier lining, leading to a leaky gut.
The lymphoid follicles are organized structures where the long-term immune attack is launched against pathogens by generating antibody response targeting the virus. These important regions are functionally impaired very early following HIV infection.
antiretroviral drugs effectively suppress viral replication, they do not repair the damage caused by the virus to the immune system. The study found that the MSCs can modulate, alter and remodel the damaged mucosal site.
without the use of antiviral drugs, MSCs were able to increase the host's antiviral response by repairing the lymphoid follicles, restoring the mucosal immunity and reviving what has been targeted by the virus very early on. How stem cells can affect viral infections such as AIDS has not been explored.
https://www.sciencedaily.com/releases/2021/06/210623194025.htm
ارسال به دوستان