How advanced flow cytometry could transform cell and gene therapy
Cell and gene therapy is an extremely promising area of biomedical research, with many breakthroughs in treatments that target genetic disorders and cancer. Although this area has seen rapid growth, companies encounter technical challenges and high costs regarding the phenotyping and profiling of cell products.
This article focuses on the role of flow cytometry in developing chimeric antigen receptor (CAR) T cells and how advanced systems may enhance workflows and facilitate bringing new therapies to the bedside.
Each stage of CAR-T cell development utilizes flow cytometry, which can be utilized early on to identify specific populations of the donor T cells associated with a better prognosis for CAR-T cell therapy.
Subsequently, the cells are continuously characterized for safety, quality, and function until they are transferred to the patient and throughput follow-up monitoring.
Advanced flow cytometry offers terrific value at many stages in developing and expanding gene and cell therapy products, such as CAR-T cells.
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