bayer claims early lead in parkinson's stem cell therapy
The hunt for Parkinson's treatments has seen many setbacks over decades. Bayer said that one year into a Phase I trial with 12 volunteers, BlueRock's therapy was shown to be well-tolerated and that transplanted cells grew as intended in patients' brains. This encouraged it to advance testing on humans to the second of three stages, with patient enrolment seen in the first half of 2024.
A slew of research projects around the globe have recently honed in on the approach to transplant modified cells to restore an area of the brain that normally produces dopamine.
For BlueRock's experimental therapy, researchers took pluripotent human embryonic stem cells and transformed them into dopamine-producing nerve cells. When surgically implanted into the brain of a person with Parkinson's disease, the therapeutic cells are designed to restore neural networks destroyed by the disease.
Initial trial results showed the cells multiplied and started making dopamine, an important brain signalling molecule which is lacking in Parkinson's patients. Parkinson's, for which there is no cure and which affects more than 10 million people worldwide, causes progressive brain damage. Common symptoms are loss of muscle control, tremors, muscle rigidity and slowness of movement while dementia is seen in some patients.
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