Pinpoint Precision for CAR-T Cell Therapy With Nanoneedles
This new method could help to catapult CAR-T therapy into a new era of targeted, efficient, and adaptable cancer treatment.
The research is developing a breakthrough technology to solve a long-standing challenge in biomedicine: how to inject genetic materials into cell interiors with much greater precision but without damaging the cells’ intricate structure.
In particular, cellular nanoinjection uses programmable electroactive nanoneedles (NNs)—powerful arrays of vertical high-aspect-ratio nanostructures—allowing to achieve an intracellular delivery, with broader cargo and cell selection, improved biocompatibility and throughput, reduced safety concerns, and more uniform delivery efficacy across the targeted cellular system.
the cytoplasm of a living cell is a crowded, dynamic place, where intracellular access and drug transport are tightly constrained to ensure healthy cell function and behaviour. Conventional approaches to accessing the cell interior for delivery and sensing are powerful, but typically perturb cell function significantly. The genius of nanoneedle technology is their capacity to give access to the cell with minimal disruption, paving the way for the optimal intracellular delivery of advanced therapeutics. The bonus is that nanoneedles give access to cells rapidly, efficiently, and at low cost, for most of the important types of cells and tissues.
The technology has only been proved in killing cancer cells in vitro; we now assess the anti-tumour efficacy of NN-engineered CAR-T cells in vivo via a preclinical human xenograft model.
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