Kidney-Like 3D Tissue Created From Stem Cells
A research team based at Kumamoto University (Japan) has created complex 3D kidney tissue in the lab solely from cultured mouse embryonic stem (ES) cells. These organoids could lead to better kidney research and, eventually, artificial kidneys for human transplant. The researchers believe that their work will advance kidney research and even lead to a transplantable organ in the future. The kidney is vital for good health because it filters extract waste and excess water from the blood. It is a complex organ that develops from the combination of three components. Dr. Nishinakamura's team at the Institute of Molecular Embryology and Genetics (IMEG) at Kumamoto University has developed a method to induce the third and final component, kidney-specific stromal progenitor, in mice. This is the first time scientists have created such a complicated structure in the lab from scratch. A similarly complicated human kidney should be possible if this last component can also be made from human cells, they say.
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