Using a mouse model, researchers from the University of Copenhagen deciphered an alternative route that certain cells take to make organs and used that knowledge to exploit a new type of stem cells as a potential source of organs in a dish.
For decades, scientists have attempted to mimic the path that stem cells follow in order to form e.g. organs in embryos. However, despite extensive efforts, making cells to properly develop in the lab has been very difficult. But they may have overlooked an important step and maybe missing another type of stem cells, suggests a new study from the University of Copenhagen.
The researchers looked at so-called pluripotent stem cells and endoderm extra-embryonic stem cells. Extra-embryonic endoderm cells are a new stem cell line that the same research team described a couple of years back. They contribute to the gut organs by being very important support cells that provide membranes, nourishment for the membranes and more.
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